DIGITAL RECONSTRUCTION OF NEURAL CIRCUITRY FOR BRAIN SIMULATION BASED ON BLUE BRAIN TECHNOLOGY

Abstract - Human brain is the most complex living structure in the universe. It is responsible for coordinating and controlling the body’s activities, interpreting information from the environment and is the centre of thought and emotion. Most of the research works are introduced with the aim of producing a biologically accurate model of the brain by combining the experimental data with powerful computer algorithms. But these works are failed to model and simulate stable neural pathways that can represent brain functions. Detailed, biologically accurate brain simulations offer the opportunity to answer some fundamental questions about the brain that cannot be addressed with any current experimental or theoretical approaches. The Blue Brain Project (BBP) is an attempt to reverse engineer the human brain and recreate it at the cellular level inside a computer simulation. BBP aims to build geometric and computational models representing different levels of the structural organization of brain. Key strategies of this project are to exploit the interdependencies in the experimental data to build comprehensive model of brain and to investigate how detailed microcircuit model can be mapped to less complex network models. In this work, a model of somatosensory system is proposed to design based on Blue Brain technology. This work comprises of the study, design, development and simulation of somatosensory nervous system using NEURON software.